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The most common side effects associated with GLP-1 agonists include appetite loss, nausea, vomiting, and diarrhea, which are often more pronounced when starting the medication or increasing the dosage (4)(10)(23)

S.TateM.ZhaoY.LockhartS.CalderwoodD.et al (2015)

This phenomenon might be noticeable in the first few weeks of treatment or after dose increases, though this mechanism has not been specifically studied in GLP-1 clinical trials

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some peptides support it more directly through metabolic signaling

Thus, they consider the activation of NLRP3 inflammasome may have little effect on APAP hepatotoxicity [265]